In this video, Graham Jackson, MBBS, FRCP, FRCPath, MD, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle, UK, highlights some of the exciting novel therapies and targets emerging in the treatment of multiple myeloma. Prof. Jackson briefly discusses novel drugs that are changing the multiple myeloma treatment landscape, including selinexor, venetoclax, and immunomodulatory imide drugs (IMiDs). To conclude, Prof. Jackson highlights the importance of novel targeted immunotherapies, such as anti-CD38 and anti-BCMA antibodies, bispecific T-cell engagers (BiTEs), and chimeric antigen receptor T-cell (CAR-T) therapy, in the treatment of myeloma. This interview took place at the 62nd Annual Scientific Meeting of the British Society for Haematology (BSH) 2022, in Manchester, UK.