In this video, Kostas Stamatopoulos, MD, PhD, Center for Research and Technology Hellas, Thessaloniki, Greece, highlights some of the main points from a session held at ESH CLL 2022, which focused on pathogenesis and transformation in chronic lymphocytic leukemia (CLL). Dr Stamatopoulos first discusses the pathogenesis of disease, where Dr Alberto Orfao gave a presentation on monoclonal B-cell lymphocytosis (MBL) and progression to CLL. Following this, Dr Stamatopoulos highlights some other talks in this session, including high-risk CLL, Richter’s transformation, and the need to better understand these in order to prevent occurrence and improve management. This interview took place during the 2nd ESH Translational Research Conference on Chronic Lymphocytic Leukemia (ESH CLL), 2022.