The Lymphoma Channel: Aggressive & Diffuse Large B-Cell Lymphoma

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The Lymphoma Channel on VJHemOnc is supported by Janssen Pharmaceuticals (a Johnson & Johnson Company), Takeda, Karyopharm Therapeutics and MorphoSys. The supporters have no influence over the production of the content.

Welcome to The Lymphoma Channel

Most types of non-Hodgkin lymphoma (NHL) form from B cells, which can be indolent (slow-growing) or aggressive (fast-growing).

Diffuse large B-cell Lymphoma (DLBCL) is the most common lymphoid malignancy in adults accounting for 30% of malignant lymphomas. It represents a heterogenous group of lymphomas involving the lymph nodes or different extranodal sites, and is an aggressive but treatable cancer.

The median age at occurrence of DLBCL is 60 years and patients usually present with disseminated disease. The standard of care for DLBCL remained the CHOP regimen for decades, which achieved long term remission rates in around 45% of patients. Following the introduction of rituximab, a chimeric anti-CD20IgG1 monoclonal antibody, long-term remission has been observed in ~60% of patients. However, a significant number of patients are rituximab refractory at relapse.Newer therapies such as CAR-T cells, immunomodulators, antibody-drug conjugates, and BTK inhibitors have further improved outcomes for patients with relapsed disease, with further research ongoing to improve outcomes for these patients, and further improve upfront therapy.

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