ASH 2023 | The development of a composite comorbidity index to predict CAR-T outcomes in patients with DLBCL
In this video, Geoffrey Shouse, DO, PhD, City of Hope, Duarte, CA, briefly discusses the development of a composite comorbidity index to predict outcomes of CAR-T therapy in patients with diffuse large B-cell lymphoma (DLBCL). This simplified cumulative illness rating scale (CIRS)-derived comorbidity index can be used as a tool to identify the patients at high risk of adverse outcomes following CAR-T. During the development of the index, the presence of a severe comorbidity in the respiratory, upper gastrointestinal, hepatic, or renal systems was found to have the most significant impact on survival. This interview took place at the 65th ASH Annual Meeting and Exposition, held in San Diego, CA.
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