The VIOLA trial (ISCRCTN98163167; EudraCT 2013-002118-11), part of the Bloodwise Trials Acceleration Program, investigated the combination of lenalidomide and azacitidine as a novel salvage therapy for acute myeloid leukemia (AML) patients who have relapsed after allogeneic stem cell transplantation. We spoke to Charles Craddock, CBE, FRCP (UK), FRCPath, DPhil, of the University of Birmingham, Birmingham, UK, about the promising recently published results. This interview took place at the International Symposium on Acute Leukemias (ISAL) 2019, held in Munich, Germany.