EHA 2024 | The optimization of induction chemotherapy for patients with AML
Marina Konopleva, MD, PhD, Albert Einstein College of Medicine, New York City, NY, discusses optimizing induction chemotherapy for acute myeloid leukemia (AML). Combining venetoclax with azacitidine (AZA+VEN) has shown effectiveness, despite lacking FDA approval. Trials incorporating anti-CD123 agents like tagraxofusp or pivekimab sunirine with AZA+VEN have improved measurable residual disease (MRD) negative rates and response duration. Another approach involves adding targeted agents for specific mutations, such as menin, FLT3, or IDH 1/2 inhibitors, to AZA+VEN. Longer randomized trials are needed to assess the impact on response depth and durability in chemotherapy-based treatments. This interview took place at the 29th Congress of the European Hematology Association (EHA) in Madrid, Spain.
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Disclosures
Research Funding: AbbVie, Allogene, AstraZeneca, Genentech, Gilead, ImmunoGen, MEI Pharma, Precision, Rafael, Sanofi, Stemline; Advisory/Consulting: AbbVie, AstraZeneca, Auxenion, Bakx, Boehringer, Dark Blue Therapeutics, F. Hoffman La-Roche, Genentech, Gilead, Janssen, Legend, MEI Pharma, Redona, Sanofi, Sellas, Stemline, Vincerx; Stock options/Royalties: Reata Pharmaceutical (IP); Patent: Novartis, Eli Lilly, Reata Pharmaceutical.
