Tuna Mutis, MD, PhD, Amsterdam University Medical Center, Amsterdam, The Netherlands, provides his highlights from the International Conference on Lymphocyte Engineering (ICLE) 2022, including presentations on the latest in T-cell receptor engineering as well as novel developments in the field of HLA-independent T-cell (HIT) receptors that will aim to optimize current chimeric antigen receptor (CAR) T-cell therapies. This interview took place at ICLE 2022.