Alessandra Tedeschi, MD, Niguarda Cancer Center, Milan, Italy, discusses the 4-year update of the iLLUMINATE study (NCT02264574) looking at ibrutinib plus obinutuzumab versus chlorambucil plus obinutuzumab as first-line treatment in patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). This interview took place at the 18th International Workshop on Chronic Lymphocytic Leukemia (iwCLL) Biennial Meeting, held in Edinburgh, UK.