Maria-Victoria Mateos, MD, PhD, from University Hospital of Salamanca, Salamanca, Spain; Faith Davies, MBBCh, MRCP, MD, FRCPath, from NYU Langone Medical Center, New York, NY, and Shaji Kumar, MD, from the Mayo Clinic, Rochester, Minnesota, discuss the changes in myeloma diagnosis criteria and the risk-stratification for smoldering myeloma. This interview took place at the International Myeloma Workshop (IMW) 2019, held in Boston, MA,