Roman Galetto, PhD, Cellectis, Paris, France, briefly discusses UCARTCS1, a novel allogeneic chimeric antigen receptor T-cell (CAR-T) therapy developed for the treatment of multiple myeloma. Dr Galetto also highlights the challenges associated with developing CAR-T products that target CS1, and the benefits of using this novel approach for the treatment of myeloma. This interview took place at the 8th World Congress on Controversies in Multiple Myeloma (COMy) 2022, held in Paris, France.