Whilst ibrutinib is effective in patients with chronic lymphocytic leukemia (CLL), fludarabine, cyclophosphamide, rituximab (FCR) is the only therapy effective in patients with mutated IGHV CLL. Matthew Davids, MD, Dana-Farber Cancer Institute, Boston, MA, presents data from the Phase II trial (NCT02251548) of ibrutinib plus FCR (iFCR) in patients with CLL regardless of IGHV status. The regimen resulted in high rates of undetectable minimal residual disease (MRD) irrespective of mutational status and after 40 months of follow-up, a majority of patients remain in deep remission. For a small number of patients who had myelodysplastic syndrome (MDS) as a result of iFCR, transplantation successfully reversed their condition. This interview took place at the 63rd ASH Annual Meeting and Exposition congress in Atlanta, GA.