David E. Avigan, MD, Beth Israel Deaconess Medical Center and Dana-Farber/Harvard Cancer Center, Boston, MA, discusses the use of vaccines and immunotherapy in hematological malignancies, including the presentation of multiple antigens on a platform of dendritic cell co-stimulation, as well as the importance of understanding the tumor microenvironment. This interview was recorded via an online conference call with The Video Journal of Hematological Oncology (VJHemOnc).