Vincent Rajkumar, MD, of the Mayo Clinic, Rochester, MN, gives an insight on the results presented at ASCO 2019 from the largest randomized controlled study in smoldering multiple myeloma looking at lenalidomide vs. observation ECOG-E3A06 (NCT01169337), and comparing these results with those from a past Spanish trial. Talking at the Controversies in Multiple Myeloma (COMy) 2019 meeting held in Paris, France, Dr Rajkumar highlights the positive results that they have found.