Charlotte Pawlyn, BA, MB BChir, PhD, MRCP, from the Royal Marsden Hospital NHS Foundation Trust, London, UK, highlights some of the interesting results from various studies in multiple myeloma relevant to UK practice, including the GRIFFIN (NCT02874742) and Cassiopeia (NCT02541383) studies. In this video, Dr Pawlyn draws focus on the daratumumab and bortezomib, thalidomide, and dexamethasone (VTD) combination in the Cassiopeia study, as well as the methodology and results from the MUK Nine b (NCT03188172) study. Dr Pawlyn also discusses the potential use of novel therapies, including CAR-T and bispecific antibodies, which may change the future of upfront therapy for multiple myeloma patients in the UK. This interview took place at the 63rd American Society of Hematology (ASH) Annual Meeting and Exposition, Atlanta, 2021.