Uwe Platzbecker, MD, University Hospital Leipzig, Leipzig, Germany, gives an update on the ongoing Phase III MEDALIST trial (NCT02631070) investigating the safety and efficacy of luspatercept in patients with lower-risk myelodysplastic syndrome (MDS) relapsed/refractory (R/R) to erythropoiesis stimulating agents. The study found that luspatercept treatment was associated with an increase of erythropoiesis biomarkers. This interview took place during the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition, 2020.