Catherine Diefenbach, MD, Perlmutter Cancer Center at NYU Langone Health, New York, NY, discusses the results of her group’s evaluation of the functional landscape of systemic immunity in classical Hodgkin lymphoma using a recently commercialized single-cell cytokine secretion platform (IsoLight) to analyze the function of peripheral blood mononuclear cells. This interview took place at the American Society of Hematology (ASH) 2019 Annual Meeting and Exposition in Orlando, FL.