Jeffrey Lancet, MD, of Moffitt Cancer Center, Tampa, FL, discusses changes in the treatment landscape for acute myeloid leukemia (AML), and suggests how it may change in the future. Improvements in AML treatment have largely been driven by a better understanding of prognostic markers and genetic therapeutic targets. Dr Lancet also explains how venetoclax and hypomethylating agent (HMA)-based therapies are expected to be utilized more in the future. This interview took place during the ninth annual meeting of the Society of Hematologic Oncology (SOHO 2021) congress.