Loretta Nastoupil, MD, University of Texas MD Anderson Center, Houston, TX, gives an overview on when to use targeted therapy in the treatment of follicular lymphoma (FL), highlighting several novel agents and trials investigating this. Dr Nastoupil first mentions some findings from the AUGMENT study (NCT01938001), which investigated the use of lenalidomide plus rituximab in relapsed/refractory (R/R) indolent lymphoma. Dr Nastoupil then draws focus on novel therapeutic agents such as tazemetostat, parsaclisib, CAR-T therapy, and bispecific antibodies, and the role that these will play in the future of targeted therapy for FL. This interview took place at the 63rd ASH Annual Meeting and Exposition congress in Atlanta, GA, 2021.