The 2022 Tandem Meetings | Dogs as a pre-clinical model for human immunotherapy research
Antonia Rotolo
• 6 May 2022
Antonia Rotolo, MD, PhD, University of Pennsylvania Veterinary School of Medicine, Philadelphia, PA, outlines the advantages of canine models in human immunotherapy research. Dogs develop spontaneous human-like cancers, with similar tumor-associated antigens and a highly similar immune response. This means that therapies can be tested in dogs and strategies can easily be translated from dogs to the clinic. In addition, due to their large size, it is possible to perform biopsies on dogs for diagnosis and monitoring, and treat dogs using a clinical schedule that would be used in human patients. This interview took place at the Transplantation & Cellular Therapy (TCT) Meetings of ASTCT™ and CIBMTR® 2022 in Salt Lake City, Utah.
