Muzaffar Qazilbash, MD, University of Texas MD Anderson Cancer Center, Houston, TX, outlines the treatment options for young patients with multiple myeloma who relapse. For the transplant-ineligible population, a number of triplet regimens are recommended. These include DRd (daratumumab, lenalidomide, dexamethasone), KRd (carfilzomib, lenalidomide, dexamethasone), ERd (elotuzumab, lenalidomide, dexamethasone), and IRd (ixazomib, lenalidomide, dexamethasone). A second autologous stem cell transplant will be offered to patients who had a long first remission and are still considered transplant-eligible. This interview took place during the 7th World Congress on Controversies in Multiple Myeloma (COMy), 2021.