Claire Harrison, MD, FRCP, FRCPath, of the Guy’s and St Thomas’ NHS Foundation Trust, London, UK, gives her perspective on the latest data in myeloproliferative neoplasms (MPNs) from the American Society of Hematology (ASH) 2018 Annual Meeting and Exposition in San Diego, CA. Key highlights include driver mutations, prognostics, and longer-term data from the MAJIC study (ISRCTN61925716).