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General Updates | Targeting CALR with immunotherapy in MPNs

Johannes Foßelteder, Medical University of Graz, Graz, Austria, comments on the potential of targeting calreticulin (CALR)-mutated myeloproliferative neoplasm (MPN) progenitors with a neoepitope-directed monoclonal antibody and with T-cells engineered to target CALR. Recent evidence from experiments in in vitro and in vivo models has shown that monoclonal antibodies and T-cells engineered to target CALR induce efficient killing of mutant cells. This interview took place virtually.