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General Updates | Using engineered CALR-mutant human HSCs to improve our understanding of MPNs

Johannes Foßelteder, Medical University of Graz, Graz, Austria, outlines the limitations of current models for calreticulin (CALR)-mutant hematopoietic stem cells (HSCs), and describes a new promising pre-clinical CRISPR knock-in model that models human CALR-mutated MPNs more faithfully and can be used to better understand the pathogenesis of MPNs or to screen for novel therapeutics. This interview took place virtually.

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