Robin Foà, MD, Sapienza University of Rome, Rome, Italy, discusses opportunities for a chemotherapy-free frontline induction treatment for patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). Prof. Foà first discusses results from the GIMEMA LAL2116 trial (NCT02744768) evaluating the use of frontline dasatinib followed by blinatumomab in Ph+ ALL, and then goes on to discuss the importance of reducing the use of chemotherapy-based regimens in this disease. This interview took place at the European Hematology Association (EHA) Congress 2022 held in Vienna, Austria.