In this video, Paola Neri, MD, PhD, University of Calgary, Calgary, AB, Canada, discusses novel therapeutic targets in multiple myeloma, including BCMA, GPRC5D, and FcRH5. Dr Neri also comments on the great potential of these targets for novel therapies, and the importance of better understanding these targets to provide patients with improved therapeutic options. This interview took place at the 8th World Congress on Controversies in Multiple Myeloma (COMy) 2022, held in Paris, France.