Many trials are ongoing in US, EU and in Europe in this setting, most of the trials are chemo free treatment, combining new proteasome inhibitors, such as carfilzomib, ixazomib with rituximab or dexamethasone, or also we start in Europe first to try out combining bortezomib, rituximab and ibrutinib in naive treatment Patients with waldenström this trial is ongoing.
And also many trials are ongoing with new BTK inhibitors, zen ibrutinib, also with acalabrutinib and also some phase two with BCL-2 inhibitors as venetoclax, but all these drugs, BTK inhibitors or BCL-2 inhibitors must be given until progression so for a long time...
Many trials are ongoing in US, EU and in Europe in this setting, most of the trials are chemo free treatment, combining new proteasome inhibitors, such as carfilzomib, ixazomib with rituximab or dexamethasone, or also we start in Europe first to try out combining bortezomib, rituximab and ibrutinib in naive treatment Patients with waldenström this trial is ongoing.
And also many trials are ongoing with new BTK inhibitors, zen ibrutinib, also with acalabrutinib and also some phase two with BCL-2 inhibitors as venetoclax, but all these drugs, BTK inhibitors or BCL-2 inhibitors must be given until progression so for a long time.
So we need to design a fixed duration chemo-free trials for stopping the drugs. And this combination could be CD20 antibodies plus BTK inhibitors or BTK inhibitors plus BCL-2 inhibitors. So we need to design new trials and fixed-duration trials.