Véronique Leblond, MD, Hematology at Pitié Salpêtrière Hospital, Paris, France, discusses common genetic variations seen in patients with Waldenström macroglobulinemia and touches on how a greater understanding of the disease, can support treatment strategies, including treatment with ibrutinib, a tyrosine kinase inhibitor. This interview was recorded via an online conference call with The Video Journal of Hematological Oncology (VJHemOnc).