Matthew Davids, MD, Dana-Farber Cancer Institute, Boston, MA, outlines the debate held between academics as to the efficacy and toxicities of cellular therapies compared to novel agents and the roles both are to play in the future of chronic lymphocytic leukemia (CLL) treatment. This interview took place at the 18th International Workshop on Chronic Lymphocytic Leukemia (iwCLL) Biennial Meeting, held in Edinburgh, UK.