Speaking at the Controversies in Multiple Myeloma (Comy) 2019 World Congress in Paris, France, Arnon Nagler, MD, of the Chaim Sheba Medical Center, Tel-Aviv, Israel, discusses the difference and progression of treatment options for multiple myeloma from 10 years ago compared to now. Prof. Nagler emphasizes the improvement in complete and overall response, but also the high cost of certain novel agents.