Simon Rule, MD, Plymouth University, Plymouth, UK, gives his insight into the mantle cell lymphoma (MCL) trials to watch out for at the American Society of Hematology (ASH) 2019 Annual Meeting and Exposition. Prof. Rule highlights the ZUMA-2 study (NCT02601313), and the use of MRD status for treatment decision-making. This interview took place at the 15th International Conference on Malignant Lymphoma (ICML), in Lugano, Switzerland.