Prithviraj Bose, MD, University of Texas MD Anderson Cancer Center, Houston, TX, shares his excitement for upcoming clinical trial updates in the myeloproliferative neoplasms (MPNs) field at ASH 2020. There will be updates on PTG-300, a novel hepcidin mimetic, for polycythemia vera (PV). Additionally, Dr Bose highlights the EXPLORER trial (NCT02561988) of avapritinib in patients with advanced systemic mastocytosis (ASM), in particular, the pure pathologic response (PPR) assessment. PPR criterion is particularly important for increasing the number of patients evaluated in future ASM trials. Lastly, Dr. Bose goes on to discuss the upcoming trials in myelofibrosis. This interview took place during the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition, 2020.