Mohamad Mohty, MD, PhD, Saint-Antoine Hospital, Paris, France, shares some insights into treatment options for patients with high-risk multiple myeloma, and how this has advanced in recent years. Prof. Mohty first explains that high-risk patients were once an unmet need in myeloma, and then goes on to discuss how combining anti-CD38 antibodies with proteasome inhibitors (PIs) and immunomodulatory imide drugs (IMiDs) has been beneficial. To conclude, Prof. Mohty shares some insights into the efficacy of combination therapy for patients who are transplant eligible and receiving consolidation and maintenance therapy, as well as the value of achieving sustained measurable residual disease (MRD) negativity. This interview took place at the 8th World Congress on Controversies in Multiple Myeloma (COMy) 2022, held in Paris, France.