Sid P. Kerkar, MD, Exuma Biotech, West Palm Beach, FL, briefly discusses the science behind cell expansion and vector design in the development of novel T-cell therapies. Dr Kerkar explains how high-throughput screening is used to find novel genes and factors that can cause T- and natural killer (NK)-like cells to proliferate, and the importance of future research in this area. This interview took place at the American Association for Cancer Research Annual Meeting in New Orleans, LA.