Michael Traxlmayr, PhD, University of Natural Resources and Life Sciences, Vienna, Austria, gives his highlights within the burgeoning field of immune cell engineering presented at the International Conference on Lymphocyte Engineering (ICLE) 2022. Notable advances include developing cellular therapies based on Foxp3+ regulatory T (Treg) cells, which will potentially represent the next generation of T-cell therapies. This interview took place at ICLE 2022.