Florence Cymbalista, MD, PhD, of Avicenne Hospital, Bobigny, France, discusses the unanswered questions in chronic lymphocytic leukemia (CLL), including considerations with new treatments, from the European Research Initiative on CLL (ERIC) International Meeting 2018, held in Barcelona, Spain. Dr Cymbalista highlights factors surrounding the need for more long-term data, treatment sequencing and differing guidelines between countries.