Nicolaus Kröger, MD, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, outlines the use of the JAK inhibitors ruxolitinib and fedratinib in patients with myelofibrosis, prior to stem cell transplantation (SCT). These JAK inhibitors have demonstrated an ability to reduce spleen size and constitution symptoms. Prof. Kröger summarizes the findings of a large study analyzing data from 500 patients, which investigated whether ruxolitinib treatment before SCT had a beneficial impact on patient outcomes. The study found that patients who received and responded to ruxolitinib before SCT had improved outcomes compared to those who did not respond to ruxolitinib and those who were not treated with ruxolitinib. This interview took place during the 47th Annual Meeting of the European Group for Blood and Marrow Transplantation (EBMT) 2021.