Here, Graham Collins, MBBS, MRCP, FRCPath, DPhil, of the Oxford University Hospitals NHS Foundation Trust, Oxford, UK, describes the most exciting aspect of CAR T-cell therapy currently. Speaking at the 1st European CAR T-Cell Meeting, held in Paris, France, Dr Collins explains the key issues with CAR T-cell therapy and the interesting presentations from the meeting that aim to address these issues. This meeting was co-organized by the European Society for Blood & Marrow Transplantation (EBMT) and European Hematology Association (EHA).