Graham Collins, MA, MBBS, MRCP, FRCPath, DPhil, Oxford University Hospitals NHS Foundation Trust, Oxford, UK, describes the mechanism of action of BTK degraders, which could be used as an additional line of BTK inhibition following failure to covalent and non-covalent BTK inhibitors. Prof. Collins then goes on to highlight NX-5948, an oral BTK degrader being investigated in relapsed/refractory (R/R) B-cell malignancies (NCT05131022).
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