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ICML 2023 | BRUIN study: updated two-year subgroup analysis of pirtobrutinib for BTKi pre-treated MCL

Chan Yoon Cheah, MBBS, Linear Clinical Research and Sir Charles Gairdner Hospital, Perth, Australia, shares the findings from a subgroup analysis of the Phase I/II BRUIN study (NCT03740529), investigating pirtobrutinib in patients with mantle cell lymphoma (MCL) previously treated with a covalent BTK inhibitor. In this updated two-year analysis, patients with high-risk MCL, such as blastoid or pleomorphic variants, achieved responses consistent with the rest of the cohort, while responses differed in two other subgroups. This interview took place at the 17th International Conference on Malignant Lymphoma (ICML), held in Lugano, Switzerland.

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