In this video, Mohamad Mohty, MD, PhD, Saint-Antoine Hospital, Paris, France, highlights some of the discussions held on day three of COMy 2022, which included debates on the use of measurable residual disease (MRD) to guide therapy, and whether autologous stem cell transplantation (autoSCT) should be replaced with immunotherapy. Prof. Mohty also highlights the possibility of combining immunotherapies with autoSCT to improve patient outcomes. This interview took place at the 8th World Congress on Controversies in Multiple Myeloma (COMy) 2022, held in Paris, France.