Jesús San Miguel, MD, PhD, University of Navarra, Pamplona, Spain, briefly explains the future of myeloma treatment and where the landscape will move, drawing focus on novel immunotherapies such as CAR-T therapy and monoclonal antibodies, and the importance of using these therapies at an earlier stage and implementing early intervention. This interview took place at the 8th World Congress on Controversies in Multiple Myeloma (COMy) 2022, held in Paris, France.