ASH 2023 | Genomic evolution of patients with CLL who progress on pirtobrutinib in the BRUIN trial
Jennifer Brown, MD, PhD, Dana-Farber Cancer Institute, Boston, MA, comments on the genomic evolution in patients with chronic lymphocytic leukemia (CLL) previously exposed to covalent BTK inhibitor (BTKi) treatment who progressed on pirtobrutinib monotherapy in the BRUIN trial (NCT03740529). Using targeted sequencing of 74 genes, the most common mutations identified at baseline were in BTK. At progression, the majority of mutations were either non-BTK or not in the target panel, suggesting that alternative resistance mechanisms are responsible. This interview took place at the 65th ASH Annual Meeting and Exposition, held in San Diego, CA.
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Disclosures
Consultancy: Loxo/Lilly, Pharmacyclics, Numab Therapeutics, Merck, Grifols Worldwide Operations, Kite, BeiGene, iOnctura, Alloplex Biotherapeutics, Hutchmed, Pfizer, Genentech/Roche, Abbvie, Acerta/AstraZeneca; Research Funding: Loxo/Lilly, TG Therapeutics, Gilead, BeiGene, iOnctura, SecuraBio, MEI Pharma.
