ASH 2024 | NCRI AML18: CPX-351 vs standard daunorubicin & cytarabine plus fractionated GO in older pts with AML
Steven Knapper, DM, FRCPath, MRCP, BMBCh, Cardiff University, Cardiff, UK, comments on the results of the NCRI AML18 trial (NCT02272478), a randomized study comparing CPX-351 versus standard daunorubicin and cytarabine (DA) plus fractionated gemtuzumab ozogamicin (GO) in older adults with acute myeloid leukemia (AML) without adverse risk cytogenetics. The trial, which ran for eight years and closed in 2022, found that standard DA and fractionated GO emerged as the preferential treatment for this group of patients, with deeper remissions and superior overall and event-free survival rates. This interview took place at the 66th ASH Annual Meeting and Exposition, held in San Diego, CA.
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