John Gribben, MD, DSc, FRCPath, FMed Sci, Barts Cancer Institute, London, UK, gives a round up of lymphoma and chronic lymphocytic leukemia (CLL) research that has been presented at the American Society of Hematology (ASH) 2019 Annual Meeting and Exposition in Orlando, FL, including longer follow-up and novel agents in early development. While majority of the updates may not be changing the therapeutic landscape completely, they none-the-less are crucial for optimizing treatment.