John Mascarenhas, MD, Mount Sinai, New York, NY, talks on novel data from an analysis of the JAKARTA (NCT01437787) and JAKARTA2 (NCT01523171) studies, which are investigating fedratinib as first-line therapy in patients with myelofibrosis and after prior ruxolitinib. Prof. Mascarenhas reports that with a median follow-up of 19 months, the median overall survival (OS) in the JAKARTA study had not been reached, and that in JAKARTA2, the median OS was not reached with a one-year OS rate of 84%. This interview took place at the virtual European Hematology Association (EHA) Congress 2021.