Michael Hudecek, MD, University of Würzburg, Würzburg, Germany, outlines the aims and key points of his talk in the Young EBMT & EHA Ambassadors session. This session is dedicated to young clinicians and scientists and aims to explain the basic science behind chimeric antigen receptor T-cells (CAR-Ts), how they were transformed into a viable product, and how CAR-Ts are evaluated. The session will also highlight clinical data on CAR-Ts. This interview took place at the EBMT-EHA 4th European CAR T-cell Meeting in which was held virtually in 2022.