Amy Burd, PhD, Leukemia and Lymphoma Society, White Plains, NY, discusses the results of the Beat AML master trial (NCT03013998). This study was designed to assess the possibility of using genetic profiling to assign older patients with previously untreated acute myeloid leukemia (AML) to molecularly defined, subtype-specific therapies. Data from this study support the use of precision medicine, patients with AML who elected for treatment assignment based upon cytogenetic and molecular alterations had significantly improved overall survival when compared with those who elected for standard of care treatment. This interview took place at the American Society of Hematology (ASH) 2019 Annual Meeting and Exposition in Orlando, FL.