In this video, Paul Hampel, MD, Mayo Clinic, Rochester, MN, discusses ibrutinib flare in chronic lymphocytic leukemia (CLL) and methods to prevent this. Dr Hampel first explains how ibrutinib flare occurs, and further emphasizes the importance of better identifying patients at risk for disease flare. This interview took place at the European Hematology Association (EHA) Congress 2022 held in Vienna, Austria.