Andrew Wei, MBBS, PhD, Alfred Hospital and Monash University, Melbourne, Australia, outlines state-of-the-art therapies for the treatment of high-risk myelodysplastic syndromes (HR-MDS). Prof. Wei highlights the use of novel immunotherapeutic agents such as magrolimab, which targets CD47, and sabatolimab, which targets TIM-3, as well commenting on the use of BCL-2 inhibitors such as venetoclax. Prof. Wei also compares therapeutic strategies for patients undergoing transplantation and for those not undergoing transplantation. This interview took place at the virtual European Hematology Association (EHA) Congress 2021.