John Seymour, MBBS, FRACP, PhD, of the Peter MacCallum Cancer Centre, East Melbourne, Australia, gives us the key updates from the MURANO study (NCT02005471) from the American Society of Hematology (ASH) 2018 Annual Meeting and Exposition in San Diego, CA. This included establishing a time-limited venetoclax-rituximab regimen for relapsed/refractory chronic lymphocytic leukemia (CLL), and the first prospective data on the impact of MRD on long-term outcomes after this therapy.